The network approach to psychopathology posits that mental disorders can be conceptualized and studied as causal systems of mutually reinforcing symptoms. This approach, first posited in 2008, has grown substantially over the past decade and is now a full-fledged area of psychiatric research. In this article, we provide an overview and critical analysis of 363 articles produced in the first decade of this research program, with a focus on key theoretical, methodological, and empirical contributions. In addition, we turn our attention (...) to the next decade of the network approach and propose critical avenues for future research in each of these domains. We argue that this program of research will be best served by working toward two overarching aims: (a) the identification of robust empirical phenomena and (b) the development of formal theories that can explain those phenomena. We recommend specific steps forward within this broad framework and argue that these steps are necessary if the network approach is to develop into a progressive program of research capable of producing a cumulative body of knowledge about how specific mental disorders operate as causal systems. (shrink)

Cyclic adenosine monophosphate (cAMP) and cAMP‐dependent protein kinase A (PKA) are evolutionary conserved molecules with a well‐established position in the complex network of signal transduction pathways. cAMP/PKA‐mediated signaling pathways are implicated in many biological processes that cooperate in organ development including the motility, survival, proliferation and differentiation of epithelial cells. Cell surface polarity, here defined as the anisotropic organisation of cellular membranes, is a critical parameter for most of these processes. Changes in the activity of cAMP/PKA elicit a variety of (...) effects on intracellular membrane dynamics, including membrane sorting and trafficking. One of the most intriguing aspects of cAMP/PKA signaling is its evolutionary conserved abundance on the one hand and its precise spatial–temporal actions on the other. Here, we review recent developments with regard to the role of cAMP/PKA in the regulation of intracellular membrane trafficking in relation to the dynamics of epithelial surface domains. BioEssays 30:146–155, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Probably to most students of Moral Philosophy there comes a time when they feel a vague sense of dissatisfaction with the whole subject. And the sense of dissatisfaction tends to grow rather than to diminish. It is not so much that the positions, and still more the arguments, of particular thinkers seem unconvincing, though this is true. It is rather that the aim of the subject becomes increasingly obscure. "What," it is asked, "are we really going to learn by Moral (...) Philosophy?" "What are books on Moral Philosophy really trying to show, and when their aim is clear, why are they so unconvincing and artificial?" And again: "Why is it so difficult to substitute anything better?" Personally, I have been led by growing dissatisfaction of this kind to wonder whether the reason may not be that the subject, at any rate as usually understood, consists in the attempt to answer an improper question. And in this article, I shall venture to contend that the existence of the whole subject, as usually understood, rests on a mistake, and on a mistake parallel to that on which rests, as I think, the subject usually called the Theory of Knowledge. (shrink)

To the question ‘What is the basis of moral obligation?’, argues that there is no general answer. It is improper to imply that all right acts are right for the same reason. Before defending this view, considers two possible grounds for moral obligation: 1) the goodness of the effects of an action, and 2) the goodness of the act itself. Whereas the former, which is broadly utilitarian, fails to comply with our real moral convictions, the latter does not capture well (...) the role that motive plays in determining the rightness of an action. Moral principles are not deducible either from one single principle or from anything that is not a principle. Each is independent and possesses its own reason as the basis for a given moral obligation. (shrink)

Natural dualities are developed for varieties ofn-valued ukasiewicz algebras with and without negation. These dualities are based on hom-functors, and parallel Stone duality for Boolean algebras. A translation is described which relates the natural dualities to the corresponding restricted Priestley dualities. This enables a unified approach to free algebras to be presented, whence R. Cignoli's characterisations of the finitely generated free algebras are elucidated and new descriptions of arbitrary free algebras obtained. Finally it is shown how dualities for subvarieties encode (...) equational bases. An alternative approach is thereby provided to results of M.E. Adams and R. Cignoli. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

What role does the wild duck play in Ibsen's famous drama? I argue that, besides mirroring the fate of the human cast members, the duck is acting as animal subject in a quasi-experiment, conducted in a private setting. Analysed from this perspective, the play allows us to discern the epistemological and ethical dimensions of the new scientific animal practice (systematic observation of animal behaviour under artificial conditions) emerging precesely at that time. Ibsen's play stages the clash between a scientific and (...) a romantic understanding of animals that still constitutes the backdrop of most contemporary debates over animals in research. Whereas the scientific understanding reduces the animal's behaviour, as well as its environment, to discrete and modifiable elements, the romantic view regards animals as being at one with (or violently disconnected from) their natural surroundings. (shrink)

I have for some time found it increasingly difficult to resist a conclusion so heretical that the mere acceptance of it may seem a proof of lunacy. Yet the failure of a recent attempt to resist it has led me to want to confess the heresy. And at any rate a statement of my reasons may provoke a refutation.

On Sikh ethics; includes brief biographies of Sikh religious leaders.

Given the generic canonical probability in phase φ=exp[β(Ψ-H)], contact is traditionally made with phenomenological thermodynamics by comparing the identity δ〈φ〉=0 with the relationTδS=δU+δW, δ indicating an arbitrary infinitesimal variation of the thermodynamic coordinates and angular brackets ensemble means. This paper is concerned with the inverse problem of finding both the generic form of the phase functionw such thatS=〈w〉 and the explicit form φ=αexp[(F-H)/kT] of the canonical distribution on the basis of the requirement that the consequences of the phenomenological laws must (...) be safeguarded, i.e., the relations between the quantities which are their concomitants must also be satisfied by their statistical representatives. Given the generic statistical formalism and specifically thatU=〈H〉, δW=−〈δH〉, the problem is soluble, granted the following generic assumption: “the statistical representative of the entropy is the ensemble mean of a function which depends upon the phase through φ alone.”. (shrink)